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关键词： 实验室检验   兽医   临床诊断  

摘要： 近年来,主要疾病的发病率相对较高,导致逐步引进了疾病流行病学、免疫学检测和生物检测,以及分子生物学检测的增加。特别是为满足现代兽医的临床需要而进行的病理测试、数据收集和病理分析等,实验室检查包括验尸、体液检查、生物检查、异常检查等,本文介绍实验室检测在兽医临床诊断中的应用。

关键词： 急性脑梗死   中医证型   检验指标  

摘要： 目的观察急性脑梗死(ACI)患者不同中医证型与检验指标差别及规律。方法收集2018年11月—2019年10月在中国中医科学院西苑医院脑病科就诊的ACI患者405例,依照中医辨证分型为风痰阻络组159例、痰浊上扰组81例、阴虚风动组37例、痰瘀阻络组45例、阴虚阳亢组38例和气虚血瘀组45例,分析不同中医证型ACI患者检验指标变化,绘制受试者工作特征(ROC)曲线评价所观察指标对中医证型的鉴别诊断价值。结果痰瘀阻络组PLT水平低于气虚血瘀组、阴虚阳亢组和风痰阻络组(P<0.01);痰瘀阻络组TCH和Apo-B水平均低于气虚血瘀组(P<0.01);痰浊上扰组PLT水平低于阴虚阳亢组(P<0.05);痰浊上扰组UA水平高于气虚血瘀组(P<0.05);痰浊上扰组Apo-A1水平高于阴虚风动组(P<0.05)。UA在鉴别气虚血瘀组和痰浊上扰组时曲线下面积(AUC)是0.662;PLT在鉴别风痰阻络组和痰瘀阻络组时AUC是0.615;PLT在鉴别气虚血瘀组和痰瘀阻络组时AUC是0.694;PLT在鉴别阴虚阳亢组和痰瘀阻络组时AUC是0.661;Apo-A1在鉴别痰浊上扰组和阴虚风动组时AUC是0.7。结论 PLT、TCH、Apo-B、UA和Apo-A1等指标,可为辨证诊治ACI提供可量化参考。

关键词： 糖尿病肾病患者   生化检验指标   临床应用效果   分析  

摘要： 目的:探讨和研究生化检验指标在糖尿病肾病早期诊断中的作用。方法:研究选取时段:2017年4月至2019年7月,研究对象:我院接诊治疗的42例糖尿病肾病患者(研究组)及同期42例健康体检者(比对组),所有患者均采取生化检验的方式,对比两组研究对象最终的检查结果。结果:研究组42例糖尿病肾病患者在生化检测后的CRP指标为(8.87±3.21)mg/L、CysC指标为(1.85±0.66)mg/L、RBP指标为(84.51±10.29)mg/L、HbAlC指标为(7.89±0.31)%、UALB/Cr指标为(65.73±6.56)mg/g,比对组42例研究对象的相关指标分别为(1.64±0.45)mg/L、(0.79±0.31)mg/L、(40.48±3.32)mg/L、(5.24±0.65)%、(4.42±1.71)mg/g,两组患者相比较来说,研究组明显较高,差异有显著性(P<0.05)。结论:在对糖尿病肾病患者进行诊断检查的过程中,可以采取生化检验的方式,其效果较为显著,可在临床中应用、推广。

关键词： 全自动血细胞分析仪   血涂片细胞形态学   血常规   检验科  

摘要： 探讨全自动血细胞分析仪联合血涂片细胞形态学在血常规检验中临床作用,以便为血常规的临床诊断提供理论依据与实践支持。方法 选取本院检验科收集的2017年1月~2018年1月入院进行血常规检验的血标本合计112份作为主要研究对象,按照试验目的对所有血标本进行全自动血细胞分析仪检测、血涂片细胞形态学检测以及两者联合检测,比较其检测结果。结果 全自动血细胞分析仪阳性率为22.32%,血涂片细胞形态学阳性率为10.71%,两者对比有统计学差异(P<0.05)。LY、MO、BA、EO、NE无报警提示标本镜检结果P值均在0.05以上,符合度较高。结论 在血常规检验中予以全自动血细胞分析仪与血涂片细胞形态学联合检验效果极佳,对提高检验质量与工作效率以及弥补两者之间的不足均有极大辅助作用,有良好的临床应用价值。

关键词： 糖尿病肾病   早期诊断   生化检验   精准性  

摘要： 目的讨论糖尿病肾病早期诊断中临床生化检验的作用。方法随机抽取本院2016年10月~2018年6月期间收治的120例糖尿病肾病患者,纳入观察组;同期抽取于本院体检者120例,纳入健康组,通过血糖检查、生化检验的方式,对其检测结果予以鉴别。结果观察组FPG、2hPG、HbAlc等血糖指标明显高于健康组,两组患者各数据间比较,存在统计学差异(P<0.05)。观察组FPG指标为(10.9±4.3)mmol/L、2hPG指标为(14.3±4.8)mmol/L;健康组FPG指标为(4.8±2.5)mmol/L、2hPG指标为(8.7±2.0)mmol/L。健康组CRP、CysC、UALB/Cr、α1-MG等生化指标值低于观察组,两组患者各数据间比较,存在统计学差异(P<0.05)。健康组CRP指标为(1.2±0.4)mg/L、UALB/Cr指标为(4.2±1.6)mg/g;观察组CRP指标为(8.7±4.7)mg/L、UALB/Cr指标为(65.8±6.8)mg/g。结论在糖尿病肾病患者早期诊断时,生化检验能够保证诊断结果的精准性,便于患者尽早治疗,保证良好的预后效果。

关键词： Bakhtin   dialogic interaction   digital literacy   glitch   human-computer interaction   interface   online writing community   screen-capture   writing  

摘要： This study, a qualitative examination of students’ experiences within an online writing community, frames human-computer interaction (HCI) as a dialogic negotiation of users and systems within networked publics. It demonstrates how an interface-level examination of these interactions, particularly at moments of glitch and error, reveals their impact on the landscape and design of educational online writing communities, puncturing the technological transparency that permeates HCI. Using a micro-ethnographic approach, this study draws from screen capture recordings, questionnaires, observations, and visual-elicitation interviews to construct two cases that demonstrate the significance of interface-level interactions in shaping the networked public square of an educational online writing community, re-framing conceptualizations of both student and system “error.” By encouraging readers to look at (rather than through) the interfaces mediating students’ interactions with online writing communities, this article shows how interface-level interactions emerge from and fold back into complex dialogic systems with implications for the teaching, research, design, and analysis of educational online writing communities. © 2020 Elsevier Inc.

关键词： Ascending thoracic aortic aneurysm   Aortic stenosis   Shear stress   CFD   Finite-element analysis  

摘要： An ascending thoracic aortic aneurysm (ATAA) is a life-threatening cardiovascular consequence of vessel dilatation that portends adverse events and death. From a clinical perspective, ATAA should not be treated as an isolated disease, and surgery is often carried out in the presence of AS, aortic insufficiency or a calcified valve leaflet. Aortic stenosis (AS) is common in ATAAs and leads to both vessel rigidity and left ventricular (LV) impairment. In this study, lumped-parameter modeling and computational analysis were used to assess the change in the wall shear stress (WSS) and intramural wall stress of patient-specific ATAA models with different degrees of AS (i.e., mild to severe). The ATAAs of four patients were reconstructed from imaging data and AS was simulated virtually using the lumped-based CircAdapt tool using clinical and echocardiographic data. Results show that LV work derived from pressure-volume loops increased with the severity of AS. Post-stenotic hemodynamic and structural variables markedly increased with AS severity, with WSS showing a 10-fold increase for the most severe AS model as compared to the baseline model with a well-functioning aortic valve. Most importantly, the increase in WSS and aortic wall stress was associated with pronounced values of valvulo-arterial impedance as an indicator of LV dysfunction. This study provides novel insights into progression of AS in patients with ATAAs at high risk of adverse events, and the potential value of valvulo-arterial impedance to predict changes in hemodynamic and structural parameters with the severity of AS. (c) 2020 Elsevier Ltd. All rights reserved.

关键词： AHR   BMI   FLD   ICD-9   IQR  

摘要： Objective: To study the interaction of alcohol consumption with body mass index (BMI) in the development of hepatic steatosis and mortality. Participants and Methods: We conducted a retrospective cohort study of 18,506 participants without fatty liver disease or cirrhosis at enrollment in the Mayo Clinic Biobank from April 9, 2009, through March 31, 2016. Participants were classified by self-reported alcohol consumption status (nondrinkers, moderate drinkers [0 to 2 drinks per day], and heavy drinkers [>2 drinks per day]). The primary outcome of interest was the incidence of hepatic steatosis, identified by International Classification of Diseases, Ninth Revision code and confirmed with imaging. The secondary outcome of interest was all-cause mortality. Multivariate Cox regression analysis determined the impact of alcohol consumption stratified by BMI on outcomes compared with nondrinkers. Results: The cohort (mean SD age, 55.8 +/- 16.9 years;63.8% female;mean +/- SD BMI, 28.8 +/- 6.1 kg/m(2)) of 18,506 participants included 3657 (19.8%) nondrinkers, 14,236 (76.9%) moderate drinkers, and 613 (3.3%) heavy drinkers at enrollment. After a median follow-up of 5.8 years (interquartile range, 3.8 to 7.2 years), 684 participants had development of hepatic steatosis and 968 died. In moderate drinkers, the risk of hepatic steatosis development was high in the obese group (adjusted hazard ratio [AHR], 1.31;95% CI, 1.03 to 1.67), insignificant in the overweight group (AHR, 0.86;95% CI, 0.58 to 1.26), and decreased in the normal-BMI group (AHR, 0.48;95% CI, 0.26 to 0.90). Heavy drinkers had an increased risk of hepatic steatosis irrespective of BMI. Moderate alcohol use was associated with decreased mortality in the normal-weight (AHR, 0.44;95% CI, 0.34 to 0.58) and overweight (AHR, 0.70;95% CI, 0.56 to 0.88) groups but not in the obese group (AHR, 0.80;95% CI, 0.64 to 1.00). Conclusion: In obese individuals, even moderate alcohol use is associated with the development of hepat

关键词： ICA   PCA   Speech   Stress   Classification  

摘要： Emotion detection is a hot topic nowadays for its potential application to intelligent systems in different fields such as neuromarketing, dialogue systems, friendly robotics, vending platforms and amiable banking. Nevertheless, the lack of a benchmarking standard makes it difficult to compare results produced by different methodologies, which could help the research community improve existing approaches and design new ones. Besides, there is the added problem of accurate dataset production. Most of the emotional speech databases and associated documentation are either privative or not publicly available. Therefore, in this work, two stress-elicited databases containing speech from male and female speakers were recruited, and four classification methods are compared in order to detect and classify speech under stress. Results from each method are presented to show their quality performance, besides the final scores attained, in what is a novel approach to the field of study.