学科服务 更多>>

关键词： Adolescence   Externalizing   Psychopathology   Reward-conditioning   Inhibitory control   fMRI  

摘要： During adolescence, rapid development and reorganization of the dopaminergic system supports increasingly sophisticated reward learning and the ability to exert behavioral control. Disruptions in the ability to exert control over previously rewarded behavior may underlie some forms of adolescent psychopathology. Specif-ically, symptoms of externalizing psychopathology may be associated with difficulties in flexibly adapting behavior in the context of reward. However, the direct interaction of cognitive control and reward learning in adolescent psychopathology symptoms has not yet been investigated. The present study used a Research Domain Criteria framework to investigate whether behavioral and neuronal indices of inhibition to previously rewarded stimuli underlie individual differences in externalizing symptoms in N = 61 typically developing adolescents. Using a task that integrates the Monetary Incentive Delay and Go-No-Go paradigms, we observed a positive association between externalizing symptoms and activation of the left middle frontal gyrus during response inhibition to cues with a history of reward. These associations were robust to controls for internalizing symptoms and neural recruitment during inhibition of cues with no reward history. Our findings suggest that inhibitory control over stimuli with a history of reward may be a useful marker for future inquiry into the development of externalizing psychopathology in adolescence.

关键词： LIBS   Infrared spectroscopy, pharmaceutical packaging   Counterfeit pharmaceuticals   Spectroscopy  

摘要： The identification of counterfeit pharmaceutical packaging is a complex problem that often requires multiple physical or chemical analyses. In this study, LIBS and ATR-FTIR were used as fast and non-invasive methods to classify pharmaceutical paperboard packaging sample into an authentic group or belonging to one of five counterfeit counterpart packaging sources. The collection set consisted of 124 external pharmaceutical packages, originating from 6 authentic sources (n = 12 packages) and 3 to 5 counterfeit sources per product (n = 112 packages). Orthogonal methods, such as LIBS and ATR-FTIR, were especially advantageous for classification purposes because they reveal chemical information of the organic and inorganic components of the package ink. Different ink colors from the logo, text, barcodes, and images were tested;additionally, the paperboard sample substrate was analyzed with ATR-FTIR. After data reduction via Principal Component Analysis, two supervised machine learning classification techniques were used for classification: k-Nearest Neighbors, and Linear Discriminant Analysis. A random 60:40 split of the data was used for training and testing the algorithms. Across all analyzed ink types, correct classification rates above 70% (LIBS) and 85% (ATR-FTIR) were observed. Data fusion of the two complementary methods improved the results, providing correct classifications ranging from 90 to 100% depending on the classifier and the pharmaceutical package. The results demonstrate that the elemental information obtained by LIBS and the chemical composition by ATR-FTIR are complementary and provide practical alternatives for fast screening of counterfeit secondary packaging.

关键词： 护理干预   检验   标本异常  

摘要： 对护理干预在降低检验标本异常率中的应用效果进行分析。方法:将在我院进行检验患者分为两个小组,分别命名为A组与B组,A组257例患者实施常规护理,B组260例患者实施护理干预,时间在2018年10月至2019年11月,比较两组患者检验标本异常率与护理总满意度。结果:与A组比较,B组患者检验标本异常率明显降低,且患者护理总满意度提升显著,数据差异具有统计学意义P<0.05。结论:护理干预在降低检验标本异常率中发挥着重要意义,为检验结果准确性提供了保证,具有推广价值。

关键词： 系统性红斑狼疮   体液免疫   核抗原抗体  

摘要： 本文需要治疗的患者是系统性红斑狼疮(SLE)患者,用当前常用的免疫学指标,对其实施各项检测,从中就其具体价值展开评定。方法:针对本次所开展的研究,选取经确诊的SLE患者,总共为84例,其中,34例正在处于活动期,其他(50例)处在非活动期,另在其同期,选取健康体检者(48例),将其当作对照组。用标准的透色比浊法,测定各项免疫指标,并且还用免疫斑点法,测定可提取核抗原(ENA),最后进行综合比对。结果:针对正处在活动期的SLE患者,其在具体的诸如IgG、IgM、IgA等免疫球蛋白水平上,相比于健康对照组,均明显升高(P<0.05),而在补体(C3、C4)水平上,与对照组作对比,明显偏低(P<0.05)。针对正处在非活动期的SLE患者来讲,其IgG、IgA水平相比于对照组患者,显著偏高(P<0.05),而两组却在C3、C4、IgM水平上,通过比对,并未发现突出差异(P>0.05)。针对活动期SLE、抗ENA阳性率与非活动期SLE抗双链DNA(ds-DNA)抗体、抗干燥综合征B(SSB)相比对照组,偏高(P<0.05);而在抗干燥综合征A(SSA)、抗U1小核糖核蛋白(nRNP)抗体上,与对照组进行对比,均明显偏高(P<0.05)。结论:对SLE患者的免疫学指标进行检验,可获得较好的诊断价值。

关键词： 护理质量控制   血液标本   标本检验  

摘要： 分析护理质量控制对提高血液标本检验准确性的重要作用。方法:自2019年7月,我院在血液标本检验工作中强化护理质量控制,分别以控制前(2018年12月~2019年6月)、后(2019年7月~2020年1月)随机抽取的1000份病理标本为研究材料,比较血液标本检验准确性差异。结果:在临床血液标本检验质量管理当中采用护理质量控制后,检验样本不合格率0.3%相比较于采用护理质量控制之前的不合格发生率1.4%有明显降低,差异值有统计学意义(P<0.05)。结论:通过强化护理质量控制,可有效提高血液标本检验的准确性,从而为临床治疗方案的制定与实施奠定坚实基础,积极影响显著。

关键词： 医学检验   护理   标本采集  

摘要： 这篇论文对医学检验质量管理中的护理工作应用进行了研究与分析,并观察精细化护理对医学检验质量管理工作的影响作用。方法:本次研究随机抽取我院妇科作为实验研究对象,并将采用精细化护理实施前(2018年10月-12月)和实施后(2019年1月-3月)的工作质量进行鲜明的对比。将实施精细化护理管理之前的检验标本作为普通护理标本采集组;将实施精细化护理管理之后的标本作为精细化护理标本采集组(每组各100份样本)。对两组所提供的标本的质量合格率进行研究与分析。结果:精细化护理标本的合格率比普通护理标本的合格率高,实验数据具有显著的统计学意义(P<0.05)。结论:在临床护理人员工作开展的过程中采用精细化护理的理念,可以使得标本的质量大幅度提高。

关键词： Feature selection   Sample classification   Gene ontology (GO)   Protein protein interaction network   Multi-view clustering   Multi-objective optimization  

摘要： BackgroundIn the field of computational biology, analyzing complex data helps to extract relevant biological information. Sample classification of gene expression data is one such popular bio-data analysis technique. However, the presence of a large number of irrelevant/redundant genes in expression data makes a sample classification algorithm working inefficiently. Feature selection is one such high-dimensionality reduction technique that helps to maximize the effectiveness of any sample classification algorithm. Recent advances in biotechnology have improved the biological data to include multi-modal or multiple views. Different 'omics' resources capture various equally important biological properties of entities. However, most of the existing feature selection methodologies are biased towards considering only one out of multiple biological resources. Consequently, some crucial aspects of available biological knowledge may get ignored, which could further improve feature selection *** this present work, we have proposed a Consensus Multi-View Multi-objective Clustering-based feature selection algorithm called CMVMC. Three controlled genomic and proteomic resources like gene expression, Gene Ontology (GO), and protein-protein interaction network (PPIN) are utilized to build two independent views. The concept of multi-objective consensus clustering has been applied within our proposed gene selection method to satisfy both incorporated views. Gene expression data sets of Multiple tissues and Yeast from two different organisms (Homo Sapiens and Saccharomyces cerevisiae, respectively) are chosen for experimental purposes. As the end-product of CMVMC, a reduced set of relevant and non-redundant genes are found for each chosen data set. These genes finally participate in an effective sample *** experimental study on chosen data sets shows that our proposed feature-selection method improves the sample classification accuracy and

关键词： 化工分析   化工检验   作用   措施  

摘要： 随着我国社会经济不断发展,近些年张家口市大力发展化工产业,这就对产品质量监督检查机构提出了新的要求,需要不断加强化工分析与检验工作,从而保证化工产品质量符合标准。基于此,本文首先探究化工分析与化工检验的重要作用,进而提出几点完善措施。

关键词： 质量控制   免疫检验   有效措施   重要作用  

摘要： 分析临床免疫检验中免疫检验分析质量控制的重要作用,探讨有效措施。方法:将2018年1月-2019年12月的140份临床免疫检测报告作为观察样本,以不同检验方法作为依据分为两组,其中70例为对照组,未进行质量控制检验,70例为研究组,进行质量控制检验,评比两组免疫检验相关指标的差异。结果:研究组同比对照组的AFP、CEA、CA125、CA199的免疫检验相关指标低,两组别的数据差异显著,具有统计学差异,P<0.05。结论:临床免疫检验中实施免疫检验质量控制有利于对检验流程进行规范,确保免疫结果的有效性、稳定性、可靠性、真实性,满足临床需求。

关键词： LIS系统开放教学   医学检验   实验教学  

摘要： 医学检验技术是一类实践应用性专业,通过LIS平台培养学生的专业素养,提高学生的心理素质,激发学习兴趣;增进学生与专业教师之间的交流,锻炼教师队伍,对提高教学质量等方面起着很好的促进作用。