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关键词： HPV   DNA methylation   cervical cancer   triage   biomarkers  

摘要： High-risk human papillomavirus (hrHPV) DNA tests have excellent sensitivity for detection of cervical intraepithelial neoplasia 2 or higher (CIN2+). A drawback of hrHPV screening, however, is modest specificity. Therefore, hrHPV-positive women might need triage to reduce adverse events and costs associated with unnecessary colposcopy. We compared the performance of HPV16/18 genotyping with a predefined DNA methylation triage test (S5) based on target regions of the human gene EPB41L3, and viral late gene regions of HPV16, HPV18, HPV31 and HPV33. Assays were run using exfoliated cervical specimens from 710 women attending routine screening, of whom 38 were diagnosed with CIN2+ within a year after triage to colposcopy based on cytology and 341 were hrHPV positive. Sensitivity and specificity of the investigated triage methods were compared by McNemar's test. At the predefined cutoff, S5 showed better sensitivity than HPV16/18 genotyping (74% vs 54%, P = 0.04) in identifying CIN2+ in hrHPV-positive women, and similar specificity (65% vs 71%, P = 0.07). When the S5 cutoff was altered to allow equal sensitivity to that of genotyping, a significantly higher specificity of 91% was reached (P < 0.0001). Thus, a DNA methylation test for the triage of hrHPV-positive women on original screening specimens might be a valid approach with better performance than genotyping.

关键词： 血液检验   贫血患者   诊断  

摘要： 目的:探析血液检验在贫血患者诊断中的作用。方法:选取2013年2月~2015年3月我院收治的80例贫血患者为研究资料,按照贫血果:不同组间的平均红细胞体积(MCV)、红细胞体积分布宽度(RDW)、平均红细胞血红蛋白浓度(MCHC)、平均红细胞血红蛋白(MCH)均具有显著差异,差异具有统计学意义(P<0.05)。结论:通过对患者的MCV、RDW、MCHC以及MCH等血液检验指标进行对比,判断患者的贫血类型,为临床诊断和治疗提供重要参考依据,值得在临床上推广和应用。

关键词： 尿常规   定性检验   糖尿病   蛋白尿   作用  

摘要： 目的分析尿常规定性检验在糖尿病蛋白尿判定中的作用,为临床提供指导。方法抽取入住该院的45例糖尿病患者(2013年10月—2015年12月)作为该次实验的研究对象,对45例糖尿病患者的临床资料进行回顾性分析,分析尿常规定性检验在糖尿病蛋白尿判定中的作用。结果 45例糖尿病患者中,有51.11%糖尿病患者在治疗期间存在一过性蛋白尿,有33.33%糖尿病患者在治疗期间存在持续性蛋白尿;经比较可知,随着患者患病时间的延长,其蛋白尿严重比率逐渐升高,各患病时间段之间蛋白尿严重比率的结果差异有统计学意义(P<0.05);随着患者年龄的增加,其蛋白尿严重比率逐渐升高,各年龄段之间蛋白尿严重比率的结果差异有统计学意义(P<0.05)。结论尿常规定性检验在糖尿病蛋白尿判定中的作用显著,可为临床医师诊断、分析和治疗疾病提供依据。

关键词： 检验标本   PDA条码   TAT  

摘要： 目的:应用无线网络和移动终端,构建检验标本生命周期全过程的跟踪管控。方法:通过移动终端扫描患者腕带,从HIS中获取患者的医嘱信息,根据检验项目从知识库中获取试管类型、标本类型和操作提示,系统对标本的各个交接和工作环节进行记录,也包括标本在实验室内的分发、保存、销毁,以及不合格标本处理过程的生命周期管理。结果及结论:简化、明晰了工作程序,加强了环节管理,规范了工作,降低了危险因素和差错发生率,提高了检验标本管理工作的准确性和实效性。

关键词： Alzheimer׳s Disease (AD)   L 2 , 1 -norm   Mild Cognitive Impairment (MCI)   Multi-modality learning   Multi-task learning   Sparse learning  

摘要： Recent studies have witnessed the effectiveness of L 2 , 1 -norm based methods on AD/MCI diagnosis. Nonetheless, most of them suffer from the following three main problems: (1) L 2 , 1 -norm based loss function does not take into account different distances between target labels and prediction values; (2) L 2 , 1 -norm based feature selection does not possess sufficient flexibility to adapt to different types of data sources and select more informative features; (3) intrinsic correlation between the processes of feature selection and classification (or regression) are inevitably ignored. In this paper, we propose a novel method which incorporates additional flexibility and adaptability by employing the more generalized L 2 , p -norm based prediction loss function and L 2 , q -norm based feature selection, as well as utilizes a joint model to perform feature selection and classification simultaneously. Besides, we introduce a regularizer to preserve local structure information between samples in the original feature space and prediction values in the projected space. In order to validate the effectiveness of the proposed method, we conducted extensive experiments on the ADNI dataset, and showed that the proposed method enhanced the performance of disease status classification, compared to the state-of-the-art methods. [ABSTRACT FROM AUTHOR]

关键词： unit root tests   multivariate time series   cointegration  

摘要： In cointegration analysis, it is customary to test the hypothesis of unit roots separately for each single time series. In this note, we point out that this procedure may imply large size distortion of the unit root tests if the DGP is a VAR. It is well-known that univariate models implied by a VAR data generating process necessarily have a finite order MA component. This feature may explain why an MA component has often been found in univariate ARIMA models for economic time series. Thereby, it has important implications for unit root tests in univariate settings given the well-known size distortion of popular unit root test in the presence of a large negative coefficient in the MA component. In a small simulation experiment, considering several popular unit root tests and the ADF sieve bootstrap unit tests, we find that, besides the well known size distortion effect, there can be substantial differences in size distortion according to which univariate time series is tested for the presence of a unit root.

关键词： wavelength selection   yerba mate   milk   cialis   viagra   PCA   KNN   PNN  

摘要： Near infrared (NIR) spectroscopy is an efficient, low-cost analytical technique widely applied to identify the origin of food and pharmaceutical products. NIR spectra -based classification strategies typically use thousands of equally spaced wavelengths as input information, some of which may not carry relevant information for product classification. When that is the case, the performance of predictive and exploratory multivariate techniques may be undermined by such noisy information. In this paper, we propose an iterative framework for selecting subsets of NIR wavelengths aimed at classifying samples into categories. For that matter, we integrate Principal Components Analysis (PCA) and three classification techniques: k -Nearest Neighbor (KNN), Probabilistic Neural Network (PNN) and Linear Discriminant Analysis (LDA). PCA is first applied to NIR data, and a wavelength importance index is derived based on the PCA loadings. Samples are then categorized using the wavelength with the highest index and the classification accuracy is calculated;next, the wavelength with the second highest index is inserted into the dataset and a new classification is performed. This forward -based iterative procedure is carried out until all original wavelengths are inserted into the dataset used for classification. The subset of wavelengths leading to the maximum accuracy is chosen as the recommended subset. Our propositions performed remarkably well when applied to four datasets related to food and pharmaceutical products. Copyright (C) 2016 John Wiley & Sons, Ltd.

关键词： 产品质量检验   质量技术监督   措施  

摘要： 产品在使用、销售等过程中,一定要保障人体健康和人身、财产安全免受伤害或损失。所以,必须要有监管部门定期的来抽查,人民群众才能用着放心。

关键词： 特种设备   检验   管理系统  

摘要： 为了加强特种设备安全监察,防止和减少事故,保障人民群众生命和财产的安全,促进经济发展,《特种设备安全监察条例》也明确要求,质监区特种设备监察机构建立特种设备动态监察网络,实时掌握特种设备安全状况,对特种设备实施有效监管,并逐步完善监控预警、安全评价、事故统计分析体系,最大程序地防止、减少事故的发生。

关键词： 多孔陶瓷   陶瓷颗粒   包装设备   一体化   分类   粒径   直线振动筛   计数装置  

摘要： 本发明公开了一种多孔陶瓷颗粒按粒径分类的一体化包装设备，包括用于分离筛选不同尺寸多孔陶瓷颗粒的直线振动筛；设置在直线振动筛下方位置处．用于承接、输送和统计多孔陶瓷颗粒数量的送料计数装置．送料计数装置的人料端相对于直线振动筛的出料端设置；设置在送料计数装置的出料端，用于输送待成型的包装纸的送膜机构。