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关键词： .MAPK   protein-protein   yeast Saccharomyces   mitogen-activated   Fus   pheromone response   MEKK   STEll   steS   interaction trap  

摘要： Ste5 is essential for the yeast mating pheromone response pathway and is thought to function as a scaffold that organizes the componentsof the mitogen-activated protein kinase (MAF K) cascade. A new method was developed to isolate missense mutations in Ste5 that differentially affect the ability of Ste5 tointeract with either of two MAPK cascade constituents, the MEKK (Stell) and the MEK (Ste7). Mutations that affect association with Ste7 or with Stell delineate discreteregions of Ste5 that are critical for each interaction. Ceimmunoprecipitationanalysis, examining the bindingin vitro of Ste5 to Stell, Ste7, Ste4 (G protein ,B subunit), and Fus3 (MAF K),confirmed that each mutation specifically affects theinteraction of Ste5 with only oneprotein. Whenexpressed in a ste5A cell, mutant Ste5 proteins that are defective in their ability to interact with either Stell or Ste7 result in a markedly reduced mating proficiency. One mutation that clearly weakened (but did not eliminate) interaction of Ste5with Ste7permitted mating at wild-type efficiency,indicating that anefficacioussignal is generated even whenSte5 associates with only a small fraction of (or only transiently with) Ste7. Ste5 mutants defective in association with Stell or Ste7 showed strong interallelic complementation when ceex- pressed, suggesting that the functional formof Ste5 in vivo is an oligomer.

关键词： identity matching   stimulus equivalence   Developmental disability   complex stimuli   computer touch screen  

摘要： This study explored whether an identity-matching-based stimulus equivalence procedure could be used to teach vowel and consonant stimulus classes to 2 adolescent females with moderate mental retardation. Delayed match-to-sample trials presented a compound sam- ple stimulus consisting of printed letters and a spoken word ( vowel or consonant ). The correct comparison stimulus matched only one of the letters in the compound sample. Subsequently, test trials assessed whether arbitrary relations had formed among the individual stimuli from each compound sample and whether stimuli from different compound samples had merged into larger stimulus classes. Both participants acquired ve-member classes of vowel and consonant stimuli, which subsequently generalized to vocal classication and to identication in the context of four-letter words. Follow-up tests showed that the generalized performances remained intact after 6 weeks. These procedures suggest an economical approach to stimulus class development.

关键词： 妇幼卫生   医学检验   妇女保健   儿童保健  

关键词： 检验   产品质量   检验类词语  

关键词： 理化检验   产品质量   企业  

摘要： 理化检验是检查和提高产品内在质量的基础技术,又是开展试验研究的重要手段.因此,做好理化检验工作,是防止产品的早期失效,提高产品可靠性和技术水平及对企业的经济发展具有极为重要的意义.

关键词： 日本   容器包装   分类收集   废弃包装处理   再商品化促进法  

关键词： LICENSE agreements  

摘要： Focuses on agreement formed by Institut Francais du Petrole with Mobil Chemical that allows IFP to license several key Mobil processes for paraxylene production. Terms on the agreement; How the agreement strengthen IFP's business with its competitors.

关键词： 感官检验   食品   质量检验  

摘要： 在“掺伪”食品监督检验中感官检验的作用蔡斌虢洪沂（山东省莒县技术监督局）感官检验是指利用人的感觉器官（如眼、耳、鼻、口、皮肤等）对产品的色泽、气味、滋味、组织结构等外观质量特性进行检查，以判定产品质量优劣，确定质量等级的方法。感官检验简便易行，不需特...

关键词： 实验动物   生物制品生产   检验  

摘要： 在生物科学领域,应用实验动物作为模型进行观察研究,包括医学研究、兽医学研究、生命科学研究、药物学研究等,均具有重要意义。作为新兴学科—实验动物学,伴随着生命科学的发展而更加引起人们的重视。本文就实验动物对兽医生物制品生产和检验的影响与作用,谈谈如下粗浅认识。1 兽医生物制品生产、检验对实验动物的要求1.1 兽医生物制品生产,特别是产品的检验,多数离不开动物实验,所以必须按照生物学研究的要求严格选择实验动物。除了按科学的再现性和反应的一致性等基本要求外,还要在实验动物的生物学特性方面符合使用目的的要求,包括遗传学和微生物学要求标准。只有这样,才能取得准确可靠的结果。

关键词： CHEMICAL industry   CONSOLIDATION & merger of corporations   CAPITAL investments  

摘要： Announces the cross-licensing agreement covering patent rights to metallocene technology by Hoechst and Fina companies. Provisions in the agreement; Hoechst and Fina as the leading players in the development of metallocene polyolefins.