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关键词： 失语/治疗   语言疗法/标准   职业病人关系   人类  

摘要： Discussions around a 'theory of therapy' have prompted attempts to delineate the components of therapy for language impairment in aphasia. Here it is suggested that the therapy components associated with how language therapy is enacted need more precise specification, especially in relation to what is entailed by interaction between therapist and person with aphasia. Presented too is a system used for the analysis of interaction in language impairment therapy for aphasia and its possible applications are discussed. Components of the system are described and a sample analysis presented. The methodological difficulties entailed in making comparisons of therapy enactment are discussed. It is suggested furthermore that unless more is known about: precisely defined interactions in therapy, it will be difficult to answer basic questions not only about how language therapy is being carried out, but also, subsequently, whether the ways in which therapy tasks are enacted have a significant impact on the outcome.

关键词： Selectivity   Multisensor systems   Medical   headspace analysis   Electronic Tongue   Electronic Nose   selectivity   group system   Food Analysis  

摘要： A combined approach based on a multisensor system, to get chemical information from liquid samples through the analysis of the solution and its head space is illustrated and commented. Sensors operating in liquid (electronic tongue) and in the head space (electronic nose) are based on the same sensitive materials: the metalloporphyrins. This gives the opportunity of a certain uniformity of interaction putting in evidence the differences between the solution and its related volatile part. The combined system has been tested in two different experiments in the fields of clinical and food analysis, respectively. Results have shown a net increase of information when the combined systems are used. The sensor fusion procedure has been optimised in order to achieve the best results. (C) 2000 Elsevier Science S.A. All rights reserved.

关键词： 商品房预售合同   形式要件欠缺   限制失效原则  

关键词： 木材检验工作   森工企业   作用   财务核算   产品质量   森林资源利用   经济效益  

摘要： 论述了木材检验工作重要性和必要性，分析了木材检验工作对提高企业经济效益的潜在因素。

关键词： 道路交通事故   驾驶员   身份确定   法医检验  

摘要： 在道路交通事故中，有时会出现汽车驾驶室内司乘人员全部被抛出车外死亡的情况。在这种情况下，对驾驶员的确认关系到确定事故责任和赔偿的主体，非常重要。 现介绍一例经过广泛调查，了解到拯救车驾驶室内司乘人员发生事故之前的饮食情况，通过检验胃内容来确认驾驶员的案例。 一、案情简介 １９９９年５月１３日２３：００时，１０７国道广州市白云区一客运站附近，南北走向双向四车道路段，粤Ａ．１００９１号拯救车，从路东客运站驶出，准备左转弯向南行驶。在横过公路时和一辆向北行驶的大货车发生碰撞。之后两车车头向西并排而停，大货车完全驶出路面，拯救车尚有部分留在路面内。 二、事故现场 拯救车上三人均被抛出车外。梁××被拯救车左后轮碾压当场死亡，尸体仰面躺在拯救车左后轮后，头向南。严××被压在大货车右后轮处，沈××倒在大货车后面偏西南的路面内，二人经抢救无效死亡。 拯救车左侧车门呈１５０”～１６０ｏ向前打开，右侧车门关闭，前面和左右两侧挡风玻璃无破裂。拯救车驾驶室内部收放机旋钮，驻车制动拉索拉杆把手、变速杆把手均变形或断裂，向左侧倾斜移位，应是发生碰撞时，三人抛出车外所造成。 驾驶室内经检查没有发现血迹、痕迹和遗留物。 三、法医检验 沈ｘＸ...

关键词： 临床检验   实验课   教学质量   考试制度  

摘要： 培养掌握一定的理论基础知识,具有较强的实际操作能力的称职的检验医师,是医学检验教学质量的要求,也是本科生检验专业教学的主要目的。医学是在科学实验与实践的基础上发展起来的一门实验科学,而临床检验专业着重要要求掌握实验操作技术,并着力培养学生的动手能力。

关键词： taxonomic resolution   sample habitat   macroinvertebrates   rivers   classification and ordination   broad-scale biomonitoring  

摘要： Macroinvertebrate biological monitoring in Victoria, Australia, has required substantial resources over the past decade, and often results have taken years to reach water managers. Ways of reducing the time and effort required in this program were examined. The influence of taxonomic resolution and sample habitat on the classification and ordination of 165 stream sites in 27 catchments across Victoria was examined by progressively reducing the level of detail in the original data. Macroinvertebrate samples were collected from 2 habitats (riffle and edge) at each site. A 3rd data set was generated by amalgamating the individual habitats. These 3 habitat treatments were analyzed at family, genus, and species level, and a 4th taxonomic treatment was generated at species level including Ephemeroptera, Plecoptera, and Trichoptera (EPT) taxa only. All 12 data sets were analyzed using presence/absence data, and each was used to classify sites across Victoria into groups that were characterized using environmental variables. The Mantel test was used to compare the 12 analyses, and showed that each of the analyses produced similar patterns. A number of possible ways to reduce time and effort in broad-scale macroinvertebrate studies were evident: 1) single habitat sampling was sufficient for biological monitoring, 2) studies that require species-level discrimination may be able to reduce costs by identifying EPT taxa only, and 3) genus-level identifications offered no substantial advantage over family-level identifications. Overall, species-level identification appeared to be unnecessary for broad-scale monitoring programs and, in future, taxonomic effort could be reduced by identifying to family level only.

关键词： .steady-state   drug interaction   concentration-time   Dosing Interval   regimens   Amprenavir   DRUG EFFECT   Interaction Modeling   Combination of Abacavir   BILELLO  

摘要： The delineation of optimal regimens for combinations of agents is a difficult problem, in part because, to address it, one needs to (i) have effect relationships between the pathogen in question and the drugs in the combination, (ii) have knowledge of how the drugs interact (synergy, antagonism, and additivity), and (iii) address the issue of true between-patient variability in pharmacokinetics for the drugs in the population. We have developed an approach which employs a fully parametric assessment of drug interaction using the equation of W, R. Greco, G, Brave, and J, C. Parsons (Pharmacol, Rev. 47:331-385, 1995) to generate an estimate of effects for the two drugs and have linked this approach to a population simulator, using Monte Carlo methods, which produce concentration-time profiles for the drugs in combination. This software automatically integrates the effect over a steady-state dosing interval and produces an estimate of the mean effect over a steady-state interval for each simulated subject. In this way, doses and schedules can be easily evaluated, This software allows for a rational choice of dose and schedule for evaluation in clinical trials. We evaluated different schedules of administration for the combination of the nucleoside analogue abacavir plus the human immunodeficiency virus type 1 protease inhibitor amprenavir. Amprenavir was simulated as either 800 mg every 8 h (q8h) or 1,200 mg q12h, each along with 300 mg q12h of abacavir. Both regimens produced excellent effects over the simulated population of 500 subjects, with average percentages of maximal effect (as determined from the in vitro assays) of 90.9% +/- 11.4% and 80.9% +/- 18.6%, respectively. This difference is statistically significant (P << 0.001), In addition, 68.8 and 46.0% of the population had an average percentage of maximal effect which was greater than or equal to 90% for the two regimens. We can conclude that the combination of abacavir plus amprenavir is a potent combination

关键词： 保险合同   保险利益   诚信原则   保险公司  

摘要： 本文是一综保险合同纠纷案分析 ,在此案中 ,被保险人既违反了诚实信用原则 ,又违反了保险利益原则 ,但由于保险人对被保险人违反诚实信用原则举证不利 ,而被保险人违反保险利益原则却显而易见 ,最后法院判决保险公司拒赔 ,但应退还保险费 。

关键词： protein folding   actin   luciferase   translation   chaperonin  

摘要： The eukaryotic chaperonin tailless complex polypeptide 1 (TCP1) ring complex (TRiC) (also called chaperonin containing TCP1 [CCT]) is a hetero-oligomeric complex that facilitates the proper folding of many cellular proteins. To better understand the manner in which TRiC interacts with newly translated polypeptides, we examined its association with nascent chains using a photo-cross-linking approach. To this end, a series of ribosome-bound nascent chains of defined lengths was prepared using truncated mRNAs, Photoactivatable probes were incorporated into these S-35- labeled nascent chains during translation. Upon photolysis, TRiC was cross-linked to ribosome-bound polypeptides exposing at least 50-90 amino acids outside the ribosomal exit channel, indicating that the chaperonin associates with much shorter nascent chains than indicated by previous studies. Cross-links were observed for nascent chains of the cytosolic proteins actin, luciferase, and enolase, but not to ribosome-bound preprolactin. The pattern of cross-links became more complex as the nascent chain increased in length,These results suggest a chain length-dependent increase in the number of TRiC subunits involved in the interaction that is consistent with the idea that the substrate participates in subunit-specific contacts with the chaperonin. Both ribosome isolation by centrifugation through sucrose cushions and immunoprecipitation with antipuromycin antibodies demonstrated that the photoadducts form on ribosome-bound polypeptides. Our results indicate that TRiC/CCT associates with the translating poly-peptide shortly after it emerges from the ribosome and suggest a close association between the chaperonin and the translational apparatus.