学科服务 更多>>

关键词： atypia of undetermined significance   follicular lesion of undetermined significance   risk of malignancy   subclassification   thyroid nodule  

摘要： Background The atypia of an undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) category in the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) is a heterogeneous category, which includes various cell patterns. The subclassification of AUS/FLUS was suggested in the 2017 TBSRTC. However, the risk of malignancy (ROM) associated with different subgroups remains unresolved. Herein, AUS/FLUS aspirates were subclassified, from which the ROM of each subgroup was determined. Methods All cases undergoing fine-needle aspiration (FNA) from July 2013 to December 2018 were reviewed. Of 12,913 thyroid FNAs, 1053 (8.2%) were AUS/FLUS. The slides of 222 patients with AUS/FLUS with surgical follow-up were reviewed and subclassified according to the recommendations of the 2017 TBSRTC. There were 195 aspirates consistently diagnosed as AUS/FLUS and subclassified as cytologic atypia 1 (AUS-C1);cytologic atypia 2 (AUS-C2);architectural atypia (AUS-A);cytologic and architectural atypia (AUS-C & A);Hurthle cell aspirates (AUS-H);atypia, not otherwise specified (AUS-NOS);and atypical lymphoid cells, rule out lymphoma (AUS-L). Results Malignancy was identified in 83.3% (185 of 222) of the AUS/FLUS nodules. The AUS-C1 group was the most common (62.1%), followed by the AUS-C&A (12.8%), AUS-C2 (10.8%), AUS-H (6.7%), AUS-NOS (5.6%), AUS-L (1.5%), and AUS-A (0.5%) groups. AUS-C1 had the highest ROM (92.6%) among the groups and varied significantly from that of the AUS-C&A (P = .171), AUS-C2 (P = .001), AUS-H (P = .001), and AUS-NOS (P < .001) groups. Conclusions As a heterogeneous category of TBSRTC, the ROM for AUS/FLUS varies greatly among medical centers. Subclassification of AUS/FLUS might be helpful in identifying nodules with a high ROM in this category and improving the management of such nodules.

关键词： Soundscapes   Sound Indices   Sonoran desert   Clustering   Environmental monitoring  

摘要： Soundscapes are increasingly used as innovative entry doors in environmental studies. Facing huge libraries of sound files which cannot be processed manually, acoustic indices provide an overview to the information contained in them, as well as to allow for automatic processing. Studies dealing with such indices have, however, focused more on specific topics or indices than on the overall characteristics of the soundscapes they were analyzing. The aim of this paper is to propose a holistic approach to soundscapes. Our hypothesis is that sufficient number and variety of indices can help frame the characteristics of sound environments and that the use of clustering algorithms allows us to group them in families and study the distribution of those across space and time, revealing a geography that will not necessarily coincide with the obvious landscape/visual geography. To demonstrate this point, we have run indices analysis and classification on a soundscapes database recorded in the Sonoran Desert region (Southeastern Arizona, USA). The results show that sound indices reveal temporal variations and patterns of soundscapes and point out to sometimes surprising similarities between otherwise different environments. As sound indices capture a wealth of information which characterizes the environment at a given place and time, they could be used as proxies to continuous monitoring without having to store extreme amounts of data.

关键词： action regulation theory   consumer welfare   decisional procrastination   implementation intention research   impulse buying   planning prompt   product category  

摘要： Extant research in the Impulse Buying domain has predominantly focused on how it can be enhanced and has mostly benefitted marketers. This study, however, shifts the focus to consumers and how they can mitigate or reduce impulse buying. Drawing on Action Regulation Theory, we posit that planning prompts mitigates impulse buying;and that this mitigating effect is stronger for individuals with high (vis-a-vis low) decisional procrastination as also for vice (vis-a-vis virtue) products. Hypotheses were tested using two studies conducted in India. Study 1 (n = 200) was conducted using a vignette-based experiment in a hypothetical scenario while Study 2 (n = 200) was a field experiment conducted on consumers in a mall setting. Our research advances knowledge with regard to mitigating avoidable impulse buying and adds to extant research on planning prompts. We also document key theoretical and managerial implications of our findings.

关键词： Concept formation   Cognitive development   Early childhood  

摘要： Background: Many cognitive tests assess a limited developmental span, making longitudinal measurement for trials aimed at improving cognition challenging. Tests targeting transitional skills, which integrate foundational abilities into complex schemas, may be amenable to assessment across a wide developmental span. Furthermore, tablet-based tests permit computer adaptive testing (CAT), which is psychometrically more efficient and could increase testing motivation, especially for children with developmental delays. Such measures may be useful for research and clinical practice. Aims: Outline the creation of a novel, tablet-based concept formation test, and evaluate its feasibility in individuals with mental ages less than 24-months. Methods and procedures: Item generation, user interface construction, and pre-piloting were conducted in consultation with subject matter experts. Item content and interface parameters underwent iterative revisions, resulting in the pilot test. Outcomes and results: We created and piloted a tablet-based test of concept formation suitable for CAT-based administration with items of increasing difficulty based on target salience. We show feasibility in individuals with mental ages less than 24-months-old. Conclusions and implications: Tablet-based assessment of concept formation may be a useful outcome measure of an aspect of cognitive ability in young children. Future work will address optimizing the user interface and developing CAT administration.

关键词： Data-driven   Business and economic sciences   Management   Science mapping   Research fronts   WoS subject categories  

摘要： The primary goal of this article is to identify the research fronts on the application of data-driven methods in business and economics. For this purpose, the research literature of the business and economic sciences Subject Categories from the Web of Science is mapped using BibExcel and VOSviewer. Since the assignment to subject categories is done at the journal level and since a journal is often assigned to several subject categories in Web of Science, two mappings are performed: one without considering multiple assignments (broad view) and one considering only those (articles from) journals that have been assigned exclusively to the business and economic sciences subject categories and no others (narrow view). A further aim of this article is therefore to identify differences in the two mappings. Surprisingly, engineering sciences play a major role in the broad mapping, in addition to the economic sciences. In the narrow mapping, however, only the following clusters with a clear business-management focus emerge: (i) Data-driven methods in management in general and data-driven supply chain management in particular, (ii) Data-driven operations research analyses with different business administration/management focuses, (iii) Data-driven methods and processes in economics and finance, and (iv) Data-driven methods in Information Systems. One limitation of the narrow mapping is that many relevant documents are not covered since the journals in which they appear are assigned to multiple subject categories in WoS. The paper comes to the conclusion that the multiple assignments of subject categories in Web of Science may lead to massive changes in the results. Adjacent subject areas-in this specific case the application of data-driven methods in engineering and more mathematically oriented contributions in economics (econometrics) are considered in the broad mapping (not excluding subject categories from neighbouring disciplines) and are even over-represented compared to

关键词： Adrenal gland thickness   reference interval   ultrasound   body weight  

摘要： Objectives Adrenal gland size and its association with body weight have been rarely evaluated in cats. This study was undertaken to assess the association between feline body weight and adrenal gland thickness, and to propose reference intervals (RIs) for adrenal gland thickness in healthy cats. Methods This was a cross-sectional study in which 39 healthy cats were included. The cats were divided into two weight categories, classified as <= 4.0 kg and >4-8 kg of ideal body weight (with 13 and 26 cats in each group, respectively), which took into consideration the body condition score of the cats. All cats underwent an ultrasound examination that was taken from a subcostal position. Maximum dorsoventral thicknesses of the left (MTL) and right (MTR) adrenal glands were measured in a sagittal plane. RIs were obtained for the maximum thickness (MT), which included the MTLs and MTRs of each cat. RIs with the 90% confidence intervals were calculated according to American Society for Veterinary Clinical Pathology guidelines on RIs. Results No statistical differences for adrenal gland thickness were observed between the left and right (P = 0.543) adrenal glands or between male and female cats (P = 0.943). Mean MT was significantly greater in the group of cats weighing >4-8 kg compared with the group of cats weighing <= 4 kg (3.7 +/- 0.6 vs 3.2 +/- 0.4 mm;P <0.005). The lower limit of the RI for MT was 2.4 mm (range 2.2-2.6 mm) in the group weighing <= 4 kg and 2.6 mm (range 2.4-2.8 mm) in the group weighing >4-8 kg. The upper limit of the RI for MT was 3.9 mm (range 3.7-4.1 mm) in the group of cats weighing <= 4 kg and 4.8 mm (range 4.6-5.1 mm) in the group of cats weighing >4-8 kg. Conclusions and relevance The use of RIs based on two group sizes allows for a more accurate ultrasonographic evaluation of adrenal gland thickness in cats. The maximum normal adrenal gland thickness is lower in smaller cats (3.9 mm for those weighing <= 4 kg and 4.8 mm for those weighing >4-8 k

关键词： Cancer   Weight loss   Body weight  

摘要： Purpose of Review Weight loss has long been known to be associated with multiple chronic conditions, including heart failure, COPD, depression, and cancer. Recent reports have suggested that unintentional weight loss (UWL) could be leveraged as an early marker of malignancy. Most studies use standardized cutoff values of >= 5% weight loss to define UWL;however, this threshold has not been validated in different body weight classifications (underweight, overweight, etc.). The purpose of this review was to describe the association between a patient's weight category, the severity of UWL prior to cancer diagnosis, cancer stage at diagnosis, and cancer-specific mortality. Recent Findings Obesity has been identified as a risk factor for many malignancies. Current data are conflicting about whether patients with obesity are more or less likely to experience UWL prior to diagnosis of a malignancy. Similarly, data analyzing the association between baseline BMI and cancer stage at diagnosis or cancer-specific mortality are mixed. UWL has been associated with an increased risk of all-cause mortality, independent of baseline BMI. Unfortunately, reliable body weight measurements are infrequently obtained, decreasing the likelihood that UWL would be detected clinically. Weight loss, when unintentional, is a serious condition which requires prompt clinical evaluation. Future studies are needed to objectively quantify UWL among patients with varying baseline BMI.

关键词： Category learning   Learning styles   Basic cognition   Classification   Family resemblance   Memory systems   Neurodiversity   Developmental disorder   Prototype & exemplar model   Computational modeling  

摘要： Similarity-based categorization, as an important cognitive skill, can be performed by abstracting a categories' central tendency, the so-called prototype, or by memorizing individual exemplars of a category. The flexible selection of an appropriate strategy is crucial for effective cognitive functioning. The detail-focused cognitive style in individuals with autism spectrum disorders (ASD) has been hypothesized to specifically impair prototype-based categorization but to leave exemplar-based categorization unimpaired. We first give an overview of approaches to investigate prototype-based abstraction in the prototype-distortion task, with an emphasis on model-based approaches suitable to discern the two strategies on the individual level. The second part summarizes literature speaking to prototype-based categorization in ASD using that task. Despite considerable inconsistencies, most studies appear to confirm that autistic individuals have more difficulties to perform prototype-distortion tasks than non-autistic individuals. We highlight how inconsistencies in literature can be resolved by taking the differences in task designs into account. The current review illustrates the need for sensitive computational approaches, suitable to detect hidden individual differences and potential compensatory strategies.

关键词： Mathematics   general  

摘要： We consider Hilbert series associated to modules over various categories of trees. Using the technology of Sam and Snowden (J Am Math Soc 30(1): 159-203, 2017) we show that these Hilbert series must be algebraic. We then apply these technical theorems to prove facts about certain natural generating functions associated to trees.